Neurologic
Read the official ruleTo qualify for a first-class medical certificate, you cannot have a medical history or diagnosis of epilepsy, unexplained loss of consciousness, or unexplained temporary loss of control over nervous system functions (like fainting, blackouts, or seizures without a clear medical cause).
Additionally, you cannot have any other neurological condition that would prevent you from safely exercising pilot privileges or that might reasonably be expected to do so during the certificate's validity period. The Federal Air Surgeon makes this determination based on your specific case history and qualified medical judgment.
This matters because first-class medicals are required for airline transport pilots. Any neurological condition that could cause sudden incapacitation or impaired function in flight is disqualifying. If you've experienced unexplained episodes, you'll need a thorough medical evaluation to determine the cause before certification. Conditions with satisfactory medical explanations may be acceptable depending on the circumstances.
*This is a plain-English summary for study only. The official 14 CFR text on this page is controlling — always read the current regulation and consult a CFI.*